Shantou University researchers found focus on gender differences in cancer
Many malignant tumors, including esophageal cancer, are characterized by high male incidence and poor prognosis. However, the mechanism behind this gender difference has been a mystery, and there is a lack of targeted individualized prevention and treatment programs in the clinic. Researchers from Shantou University found that the androgen receptor AR signaling pathway plays an important regulatory role in the persistent inflammatory response of tumors caused by unhealthy lifestyles. This result uncovers the mystery of gender differences in esophageal cancer from a perspective, as a life behavior factor. The importance of interaction with in vivo genes in cancer provides new evidence and offers new options for personalized prevention and intervention in esophageal cancer. The research results were published in The Journal Pathology magazine on November 1. The research led by Professor Zhang Wei, director of the Cancer Research Center of Shantou University, including Shanghai Key Laboratory of East China Normal University and molecular cells of Baylor Medical College, USA. Professor Li Xiaotao, Department of Biology, and other research groups. Professor Zhang has made many important achievements in tumor transformation research in recent years. Esophageal cancer is one of the most common malignant tumors of the digestive tract, accounting for the top six cancer deaths worldwide. China is a country with high incidence of esophageal cancer, and the number of patients accounts for more than half of the world. At present, esophageal cancer lacks corresponding targeted drugs and specific diagnostic markers, and the 5-year survival rate is only 20-40%. One of the characteristics of esophageal cancer is high in men and the prognosis is worse than in women. In fact, many tumors such as liver cancer, stomach cancer, and esophageal cancer are all male and female. This problem is a long-standing concern in clinical and basic related fields, and has never been solved. Professor Zhang Wei of Shantou University Medical College conducted a cohort analysis of multiple patient samples and found that the expression level of AR in smoking patients is closely related to the prognosis. At the same time, in vitro and in vivo experiments showed that abnormal expression of AR can promote tumor growth and progression. In view of the male-dominated lifestyle behaviors such as smoking, which can lead to chronic inflammatory reactions in cells, the researchers found that the inflammatory factor IL-6 is a novel target gene regulated by AR through microarray screening, bioinformatics analysis and molecular biology. Later, it was further found that AR and IL-6 form a feedback loop, and the tumors are promoted by repeated activation of the oncogene pathway such as STAT3. This indicates that AR plays a role in mediating and bridging the cancer-related irreversible inflammation caused by lifestyle behaviors such as smoking. This study unveils the mystery of gender differences in esophageal cancer from a single perspective, providing new evidence for the importance of life behavior factors and in vivo genetic interactions in cancer, and provides new options for personalized prevention and intervention of esophageal cancer. Blackout greenhouse ,Light dep greenhouse ,Auto light deprivation greenhouse,Blackout green house,film greenhouse JIANGSU SKYPLAN GREENHOUSE TECHNOLOGY CO.,LTD , https://www.engreenhouse.com