Ministry of Health announces latest measles vaccine booster

The Ministry of Health announced the latest measles vaccination booster quiz, as follows:

1. Has the child injected tetanus immunoglobulin (or rabies immunoglobulin, anti-rabies serum) for measles vaccination?

Can be inoculated. Tetanus immune globulin (or rabies immunoglobulin, anti-rabies serum) are all specific immunoglobulins and may only affect the inoculation of tetanus vaccine (or rabies vaccine), but generally have no effect on the effectiveness of measles vaccination .

2. Propaganda of bovine colostrum indicates that the product contains immunoglobulin components. If it is taken, can it be vaccinated against measles?

Injection of immunoglobulin within 3 months may affect the inoculation of the measles vaccine and delay inoculation. However, foods that may contain immunoglobulin generally have no effect on the effectiveness of the measles vaccine and can be inoculated.

3. Parents saw the contraindications to measles vaccine vaccination: they have suffered from or are suffering from multiple neuropathies, Guillain-Barre syndrome, acute disseminated encephalomyelitis, encephalopathy, epilepsy and other serious neurological diseases, or other progressive Nervous system disease. What is involved in consulting encephalopathy? For example: mycoplasma encephalitis, viral encephalitis, mitochondrial encephalomyopathy, hyperactivity disorder, cerebral palsy, and autism.

Encephalopathy is a group of central nervous system disorders that have seizures, severe disturbances of consciousness, or behavioral disorders. Mycoplasmal encephalitis, viral encephalitis, mitochondrial encephalomyopathy, hyperactivity disorder, cerebral palsy, and autism are diseases that affect or may affect the nervous system. Vaccination against measles is not recommended.

4. Can the measles be vaccinated during tooth extraction (drugs are unknown)?

During tooth extraction, there may still be signs of pain, swelling, etc., and it is recommended to re-apply after rehabilitation.

5. How long does it take to vaccinate against measles after applying immunomodulators (pyridamole, etc.)?

Immunomodulators may have an impact on the effectiveness of the measles vaccination and it is recommended that they be replanted three months later.

6. Children are allergic to dust mites and molds. They need three-year desensitization needles, two injections a week, and can they be vaccinated against measles?

Allergies to dust mites and molds are not necessarily allergic to measles vaccines, but children “need to inoculate desensitizing needles for three years and inject two needles per week.” This indicates that heavier allergies may be present. Inoculation is generally not recommended. Should be closely watched.

7. Is growth hormone injected? Can it be vaccinated against measles?

Growth hormone may interfere with the immune effects of the measles vaccine and delay inoculation.

8. Inquiring about the measles-enhanced vaccine campaign, why should the vaccine be sponsored by the Lanzhou Institute of Biological Products at a low price? Was the brand of measles vaccine previously used in Beijing's planned immunization? What is the success rate of the brand's previous vaccination? What is the incidence of adverse reactions?

The measles vaccine used for the immunization is mainly provided by four large-scale state-owned vaccine companies, including the Lanzhou Institute of Biological Products, the Shanghai Institute of Biological Products, the Wuhan Institute of Biological Products, and Beijing Tiantan Biological Products Co., Ltd. Vaccine and syringe funds are transferred from the central government and allocated to the provinces. Vaccines are organized and purchased by provinces. The tender price of vaccines is uniformly priced by the National Development and Reform Commission. There is no question of “low prices” or high prices. The measles vaccines used in China's immunization program are mainly measles and rubella combined vaccines and measles and rubella mumps vaccines. Vaccines are generally selected for immunization in various countries. The success rate of immunization against measles vaccines is related to the age of inoculation. Usually 8 months after inoculation, the success rate is 85%, and the inoculation can reach 95% or more after 18 months of age.

According to the World Health Organization's study on the adverse reactions of measles-containing vaccines (measles / leprosy / phlegm vaccine), the general reaction rates were: local pain, swelling, blush about 10%, and fever greater than 38 °C. 5-15% irritability, discomfort, and systemic symptoms (including mild rash or conjunctivitis, arthralgia) were 5%; the incidence of abnormal reactions were: fever convulsions 330/1 million doses, thrombocytopenia 30/100 10,000 doses of acute allergic reactions without shock, 10/100 doses, 1/1 million doses of anaphylactic shock, and less than 1 million doses of encephalopathy.

According to the monitoring results of past measles vaccine-enhanced immunization in some provinces of China, the incidence of abnormal reactions of measles vaccine was: 8.6/1 million doses of allergic rash, 1.6 million doses of anaphylactoid purpura, and 0.3/1 million doses of angioedema. Secondly, 0.2/1 million doses of anaphylactic shock, 0.2/1.0 million doses of thermal convulsions, and 0.1/1 million doses of thrombocytopenic purpura, and 0.1/1 million doses of Arthus reaction.

9. The Ministry of Health announced that the measles vaccine has been used for 44 years. Is the vaccine produced by the Lanzhou Institute of Biological Products used for the booster immunization?

Vaccines are purchased by the provinces. Different provinces and cities may bid to purchase vaccines from different manufacturers. However, the vaccines were all qualified after approval by China National Institute of Biological Products.

The measles vaccine used for the immunization is mainly provided by four large-scale state-owned vaccine companies, including the Lanzhou Institute of Biological Products, the Shanghai Institute of Biological Products, the Wuhan Institute of Biological Products, and Beijing Tiantan Biological Products Co., Ltd.

10. The measles vaccine was domestically produced, but where is the origin of measles vaccine research and development? Is the initial R&D of domestic R&D? Or is the vaccine research and development place abroad, it is only imported from abroad and it is produced in domestic quantities?

The measles vaccine in China has been developed almost simultaneously with other countries. At present, the measles vaccine in China mainly uses Shanghai 191 live attenuated measles vaccine strain.

Shanghai 191 strains were separated from the blood of a 2-year-old boy during the epidemic of Shanghai measles in 1960. They were transmitted in the primary human embryonic kidney cells for 33 generations, human amniotic cells were passaged for 39 generations, and chicken embryo cells were passaged for 10 generations after clinical trials. In 1965, the Ministry of Health approved production, and by 1985 it was changed to a lyophilized dosage form. In 1991, the National Institute of Public Health and Environmental Protection of the Netherlands (Chinese Vaccine Project) helped with purification and was confirmed by inspection by the Central Inspection Agency to establish a purified strain.

After more than 40 years of use, it has been proved that Shanghai 191 has the same immunogenicity and protective effect as other commonly used strains (Swas and Leningrad 16 strains) in the world.