Hot and cold intelligent induction ablation catheter for FDA approval for atrial fibrillation ablation
Release date: 2014-03-04 Source: China Medical Technology Network
Intermediate – Intermediate: A material produced during a drug substance processing step that must undergo further molecular modification or refinement to become a drug substance. Intermediates may or may not be isolated. Intermediates are the key products of the previous process of making APIs, which are different in structure from APIs.
Ceftriaxone sodium powder is called preparation, sterile ceftriaxone sodium is called API, and 7-ACA is called intermediate.
Our company specializes in providing key intermediates for various APIs
Intermediate is a very important type of fine chemical products. Its essence is a type of "semi-finished product", which is an intermediate product in the production of certain products. For example, if a product is to be produced, it can be produced from intermediates, saving costs and reducing It is widely used in the synthesis of medicines, pesticides, coatings, dyes and spices. In the field of medicine, intermediates are an important link in the industrial chain of the pharmaceutical industry. They are used for some chemical raw materials or chemical products in the process of drug synthesis. In a word, they are used to produce APIs.
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Recently, the FDA approved a radio frequency ablation catheter, the ThermoCool SmartTouch ablation catheter, which can be fed back in real time. The contact pressure measuring catheter can sense its contact with heart tissue and can be used for patients with paroxysmal symptomatic atrial fibrillation who are not responding to arrhythmia drugs. The FDA approved the use of the catheter based on the results of the SMART-AF trial reported last year by the American Heart Rhythm Society.
The SMART-AF trial showed that 69% of 172 patients had no atrial fibrillation, atrial flutter or other tachyarrhythmia at 1 year of ablation. This ratio increases when the operator maintains contact for at least 80% of the time. Dr. Andrea Natale, one of the principal investigators at the Arrhythmia Institute at St. David's Medical Center in Texas, reported that exposure was associated with the quality of lesion ablation.
The safety of the catheter has been confirmed, with a 7-day adverse event rate of 9.9%, which is lower than 16.6% of historical data.
The catheter's real-time feedback features allow clinicians to sense contact forces during surgery, thereby more ablating diseased tissue, achieving better clinical outcomes, and minimizing the risk of tissue damage. 
for example:
Amoxicillin capsules are called preparations, amoxicillin is called API, and 6-APA is called intermediate.
