Small-Molecule Inhibitor API Azd-4547 (CAS: 1035270-39-3)

November 01, 2018

Model NO.: Pharmaceutical Grade
Product Name: Azd-4547
Model No.: Atc-168
Molecular Formula: C26h32n5o3
Molecular Weight: 462.56398
Product Specifications: Pharmaceutical Grade
MOQ(Minimum Order Quantity): 10g
Origion: Hubei, China
Brand: Biocar
Market: Global
Trademark: NEWBIO PHARMTECH
Transport Package: Aluminum Foil Bag or as Required
Specification: SGS/ CTI/ ITS
Origin: Wuhan, Hubei, China
HS Code: 8676530000
Model NO.: Pharmaceutical Grade
Product Name: Azd-4547
Model No.: Atc-168
Molecular Formula: C26h32n5o3
Molecular Weight: 462.56398
Product Specifications: Pharmaceutical Grade
MOQ(Minimum Order Quantity): 10g
Origion: Hubei, China
Brand: Biocar
Market: Global
Trademark: NEWBIO PHARMTECH
Transport Package: Aluminum Foil Bag or as Required
Specification: SGS/ CTI/ ITS
Origin: Wuhan, Hubei, China
HS Code: 8676530000
High Purity Small-Molecule Inhibitor API Azd-4547 (CAS: 1035270-39-3)
 
Chemical Information
Quick Details:
Product Name Azd-4547
Molecular Formula C26H33N5O3
Molecular Weight 463.57
Storage 3years in -20ºC
Targets FGFR1     FGFR2    FGFR3
IC50 0.2 nM
IC50 2.5 nM
Dosage /
Product Name: AZD-4547
Other Name:AZD-4547;rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide;AZD4547/AZD-4547;AZD4547, Free Base, >99%;rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide AZD4547;N-(5-(3,5-Dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3R,5S)-rel-3,5-dimethylpiperazin-1-yl)benzamide
Model No.: ATC-168
CAS No.: 1035270-39-3
Molecular Formula: C26H32N5O3
Molecular Weight:462.56398
Stability: N/A
Target:N/A
Appearance: Pale Yellow Solid
Melting Point: N/A
Purity: 99%+
 
Product Description
AZD4547 is a novel selective inhibitor of FGFR for FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38.

AZD4547 is a potent, specific, orally bioavailable fibroblast growth factors receptor (FGFR) tyrosine kinase inhibitor. It inhibits FGFR1, FGFR2, and FGFR3 with IC50 values of 12, 2 and 40 nM, respectively. AZD4547 has also been reported to block FGFR1, FGFR2, and FGFR3 autophosphorylation with IC50 values of 0.2, 2.5, and 1.8 nM, respectively [1].

AZD4547 has been demonstrated to inhibit cell proliferation and inhibit FGFRs and their downstream markers including PLCg and FRS2 phosphorylation in breast cell line Sum52-PE (expressing wild-type FGFR2), multiple myeloma line KMS11 (expressing Y373C mutated FGFR3 protein) and acute myeloid leukemia cell line KG1a (expressing wild-type FGFR1) [1].

Anti-carcinoma effect of AZD4547 has been observed in lung cancer xeonograft mice orally treated with AZD4547. This effect is believed to be via the specifically inhibition of the activity of FGFR but not kinase insert domain receptor (KDR)[1].

 
Applications/Usage
AZD4547 is a bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinases. AZD4547 is particularly effective in inhibiting FGFR1, 2, and 3 tyrosine k inases and is under clinical investigation for the treatment of FGFR-dependent tumors.
 
 
 
====================================================
 
Our Advantages
1.High quality and competetive price
1)For exported we can offer COA Certificate and official Invoice.
2)We are manufacturer with own lab and factory, can provide high quality products with factory price. 
3)Products purity is test by our quality department strictly before sending, and you can also ask the third testing organization come and inspect, such as (SGS/ CTI/ ITS), only after your confirmation will we send it out to you.
 
2.Fast and safe delivery:
1)Products can be sent out in 24 hours after payment. Tracking number available, fixed service person are 7X24h for you to contact.
2) Secure and discreet shipment. Various transportation methods for your choice, like DHL/UPS/TNT/FedEx/SF-express.
3)Customs pass and satisfied rate ?Y99%.
4)For hot sale products we have stock in there for transferring. 
 
3 We have clients throughout the world:
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire. 
2) Market feedback and goods feedback will be appreciated, meeting customers' requirement is our responsibility. 
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers. 
 
1.The parcels will be sent within 24 hours once the order is verified.
2.Packaging is fully in accordance with customer demand.
3.There will be discounts whether you are an old customer or not.
 
BioCar's Featured Products:
 
AZD9291 1421373-65-0
E7080 417716-92-8
Afatinib diMaleate 439081-18-2
XL184 S-MALATE 1140909-48-3
Crizotinib 877399-52-5
Axitinib 319460-85-0
WZ4002 1213269-23-8
Vandetanib 443913-73-3
Sunitinib 557795-19-4
Regorafenib 755037-03-7
Imatinib 152459-95-5
 
Delivery Time
About 7 days

====================================================
 
Contact Us
Tel: 86-027-86879876
Mobile: 86-15327198583
Fax: 86-27-87050469
Website: http://www.besteroid.com/
Online Store:http://biocar.en.made-in-china.com/
©Wuhan Biocar Bio-Pharm Co., Ltd.
 



Delivery:
1) Products can be sent out within 24 hours after payment. 
2) Secure and discreet shipment. 
3) Various methods for your choice, like DHL/TNT/FedEx/SF-express.
 

Commitment:
1. We are manufacturer with own factory and we sale this product at a best quality and low price.
2. This product is available in stock, please contact the sale for more details.
3. We have QA & QC department to guarantees the ex-factory product pass rate can reach 100%. 


====================================================
Contactct:
Telephone: +86-027-87002705
Mobile: +86-13638641831 +86-13277093700
 
 
FaceBook: https://www.facebook.com/newbiopharma/
Website:  http://www.newbiopharm.com/
Online Store: http://biocar.en.made-in-china.com/
©Wuhan Newbio Pharm-Tech Co., Ltd.


Newbio is a reliable supplier and looks for a long term business relationship!!!

High Purity Small-Molecule Inhibitor API Azd-4547 (CAS: 1035270-39-3)
 
Chemical Information
Quick Details:
Product Name Azd-4547
Molecular Formula C26H33N5O3
Molecular Weight 463.57
Storage 3years in -20ºC
Targets FGFR1     FGFR2    FGFR3
IC50 0.2 nM
IC50 2.5 nM
Dosage /
Product Name: AZD-4547
Other Name:AZD-4547;rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide;AZD4547/AZD-4547;AZD4547, Free Base, >99%;rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide AZD4547;N-(5-(3,5-Dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3R,5S)-rel-3,5-dimethylpiperazin-1-yl)benzamide
Model No.: ATC-168
CAS No.: 1035270-39-3
Molecular Formula: C26H32N5O3
Molecular Weight:462.56398
Stability: N/A
Target:N/A
Appearance: Pale Yellow Solid
Melting Point: N/A
Purity: 99%+
 
Product Description
AZD4547 is a novel selective inhibitor of FGFR for FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38.

AZD4547 is a potent, specific, orally bioavailable fibroblast growth factors receptor (FGFR) tyrosine kinase inhibitor. It inhibits FGFR1, FGFR2, and FGFR3 with IC50 values of 12, 2 and 40 nM, respectively. AZD4547 has also been reported to block FGFR1, FGFR2, and FGFR3 autophosphorylation with IC50 values of 0.2, 2.5, and 1.8 nM, respectively [1].

AZD4547 has been demonstrated to inhibit cell proliferation and inhibit FGFRs and their downstream markers including PLCg and FRS2 phosphorylation in breast cell line Sum52-PE (expressing wild-type FGFR2), multiple myeloma line KMS11 (expressing Y373C mutated FGFR3 protein) and acute myeloid leukemia cell line KG1a (expressing wild-type FGFR1) [1].

Anti-carcinoma effect of AZD4547 has been observed in lung cancer xeonograft mice orally treated with AZD4547. This effect is believed to be via the specifically inhibition of the activity of FGFR but not kinase insert domain receptor (KDR)[1].

 
Applications/Usage
AZD4547 is a bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinases. AZD4547 is particularly effective in inhibiting FGFR1, 2, and 3 tyrosine k inases and is under clinical investigation for the treatment of FGFR-dependent tumors.
 
 
 
====================================================
 
Our Advantages
1.High quality and competetive price
1)For exported we can offer COA Certificate and official Invoice.
2)We are manufacturer with own lab and factory, can provide high quality products with factory price. 
3)Products purity is test by our quality department strictly before sending, and you can also ask the third testing organization come and inspect, such as (SGS/ CTI/ ITS), only after your confirmation will we send it out to you.
 
2.Fast and safe delivery:
1)Products can be sent out in 24 hours after payment. Tracking number available, fixed service person are 7X24h for you to contact.
2) Secure and discreet shipment. Various transportation methods for your choice, like DHL/UPS/TNT/FedEx/SF-express.
3)Customs pass and satisfied rate ?Y99%.
4)For hot sale products we have stock in there for transferring. 
 
3 We have clients throughout the world:
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire. 
2) Market feedback and goods feedback will be appreciated, meeting customers' requirement is our responsibility. 
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers. 
 
1.The parcels will be sent within 24 hours once the order is verified.
2.Packaging is fully in accordance with customer demand.
3.There will be discounts whether you are an old customer or not.
 
BioCar's Featured Products:
 
AZD9291 1421373-65-0
E7080 417716-92-8
Afatinib diMaleate 439081-18-2
XL184 S-MALATE 1140909-48-3
Crizotinib 877399-52-5
Axitinib 319460-85-0
WZ4002 1213269-23-8
Vandetanib 443913-73-3
Sunitinib 557795-19-4
Regorafenib 755037-03-7
Imatinib 152459-95-5
 
Delivery Time
About 7 days

====================================================
 
Contact Us
Tel: 86-027-86879876
Mobile: 86-15327198583
Fax: 86-27-87050469
Website: http://www.besteroid.com/
Online Store:http://biocar.en.made-in-china.com/
©Wuhan Biocar Bio-Pharm Co., Ltd.
 



Delivery:
1) Products can be sent out within 24 hours after payment. 
2) Secure and discreet shipment. 
3) Various methods for your choice, like DHL/TNT/FedEx/SF-express.
 

Commitment:
1. We are manufacturer with own factory and we sale this product at a best quality and low price.
2. This product is available in stock, please contact the sale for more details.
3. We have QA & QC department to guarantees the ex-factory product pass rate can reach 100%. 


====================================================
Contactct:
Telephone: +86-027-87002705
Mobile: +86-13638641831 +86-13277093700
 
 
FaceBook: https://www.facebook.com/newbiopharma/
Website:  http://www.newbiopharm.com/
Online Store: http://biocar.en.made-in-china.com/
©Wuhan Newbio Pharm-Tech Co., Ltd.


Newbio is a reliable supplier and looks for a long term business relationship!!!

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