The chairman of Huada Gene said that "there is nothing to do to fight the cervical cancer vaccine"

In July 2017, the Chinese mainland broke the situation of no cervical cancer vaccine, and it was finally introduced ten years later. However, the high price of vaccines, the effectiveness of vaccines, and the safety to be observed are still arguing about the issue of “the vaccine should not be hit”.

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On December 20, Wang Jian, chairman of China's gene sequencing industry leader, Huada Gene, revealed his personal views in a video interview with Tencent Finance. In response to the phenomenon that some Chinese women choose to inject cervical cancer vaccine into the United States or Hong Kong, Wang Jian clearly stated, "I oppose, the vaccine is 4,000 yuan, once every 5 years, you do early detection, 50 dollars, 3 years test once ."

The so-called cervical cancer vaccine refers to the human papillomavirus HPV vaccine. First listed in the US in 2006, it is also the world's first vaccine to prevent cancer.

Regarding the preventive measures that have been implemented in foreign countries for more than 10 years, Wang Jian believes that it is more concerned with the "economic account" and the results. "Play once in 5 years, you were originally one thousandth, one ten thousandth chance. Of course, if you have more money, you have nothing to do. There is no problem for ordinary people. It is better to go to the ordinary people to do a test." Wang This cervical cancer prevention measure, which is a relatively high price to vaccinate, is like "as if you sent the guards on the mountain", and then compared the genetic test he admired to "the drone has been inspected for half a month." He called this "a different prevention plan, it is completely business-oriented."

Wang Jian also added that "the foreigner's vaccine has many subtypes that are different from China's, and can't believe it." The HPV genotyping test that Huada Gene has long launched has claimed that it can be used for all 14 high-risk HPV types. And the main pathogenic viruses of the two reproductive tracts (6, 11 subtypes) are accurately typed. The data shows that up to now, Huada's HPV test samples have exceeded 2.5 million, covering 72 cities in 27 provinces across the country.

However, Wang Jian’s remarks have sparked controversy in the industry. The main controversy is whether early detection is equivalent to vaccination.

Both are not a prevention level

Controversial voices point out that, like any other disease, cervical cancer also has three lines of defense, which is a three-level preventive measure. Among them, vaccination is equivalent to the first level of disease prevention, that is, the prevention of the cause, the measures taken when the disease has not occurred, and the measures taken to prevent, control and eliminate the disease, and it is necessary. of.

The HPV genetic test and another TCT test are in the scope of secondary prevention, that is, preventive measures taken to prevent or slow the progression of the disease during the incubation period of the disease. Unlike HPV vaccination, once the gene detects HPV, the infection has already occurred.

Of course, being infected with HPV is not the same as having cervical cancer. Professor Wang Huaying from the Department of Oncology, Fudan University Cancer Hospital, once said, “There must be persistent infection to have cancer. Humans have their own immune system and can resist the invasion of the virus. Generally 60% to 70% of patients can rely on their own immunity to clear the infection. Only 20% to 30% of patients will have persistent infections." And continue to infect precancerous lesions, which can last for several years to ten years. For this reason, even if the HPV vaccine is given, experts recommend regular early detection.

In addition to the level of prevention can not be confused, Wang Jian mentioned "five years of playing once" also caused controversy, saying that the current vaccine product specification and cervical cancer prevention guidelines have not recommended five years of vaccination, how long is the protection period of HPV vaccine? There is no long-term large sample of data yet.

The main limitation of HPV vaccine is that it cannot be "100% preventive"

The controversial voice admitted that the HPV vaccine does have limitations. The main reason is that the currently marketed vaccine does not fully cover the HPV subtype.

There are hundreds of subtypes of HPV, of which more than 30 can cause disease, and can be divided into high-risk and low-risk types. At least 14 high-risk subtypes of HPV are currently known, with the 16 and 18 subtypes being the most at risk.

There are currently three HVP vaccines for the prevention of cervical cancer worldwide. Merck's HPV vaccine tetravalent Gardasil is aimed at HPV16, 18, 6, and 11 subtypes. HPV vaccine nine-valent Gardasil adds 31, 33, 45, 52, and 58 HPVs to the original four subtypes. Viral subtypes; In addition, GlaxoSmithKline's bivalent vaccine Cervarix is ​​targeted at HPV 16, 18.

Qi Long, director of the Cervical Diseases Treatment and Treatment Center of the Obstetrics and Gynecology Hospital affiliated to Fudan University, once mentioned that vaccination can prevent the majority of cervical cancer, but it cannot be 100% protective. "Even HPV vaccine pairs 16, 18 High-risk subtypes of HPV have a protective power of 100%, and a significant proportion of women may have cervical cancer due to persistent infection with high-risk HPV other than the 16 and 18 subtypes."

However, given the highest risk of Types 16 and 18, these vaccines can prevent a higher proportion of cervical cancer. According to the data given by Xiaolong, the cervical and cancer patients found in Shanghai accounted for 70% of the 16 and 18 subtypes.

At present, the two countries have approved the listing of divalent and tetravalent in China, and the more comprehensive nine-price coverage of HPV subtypes has not entered clinical trials in mainland China. (China Youth Daily)

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