Quantum dot-labeled stem cells target pancreatic tissue of diabetic rats
At present, the number of people with diabetes in China is increasing year by year, accounting for 11.6% of the total number of people with diabetes worldwide. Type I diabetics have impaired islet B cells and are unable to produce enough insulin to regulate blood sugar levels. Cellular therapies that currently restore islet B cell function include pancreas transplantation, islet transplantation, and stem cell transplantation, in which mesenchymal stem cells (MSCs) are most easily transplanted. MSCs have been used in the treatment of a variety of diseases including diabetes, but the distribution and therapeutic mechanisms of transplanted MSCs in vivo are not clear. Yongquan Shi of Changzheng Hospital and Daxing Cui of Shanghai Jiaotong University marked the mesenchymal stem cells with quantum dots and injected them into diabetic rats through the tail vein. The distribution of stem cells was observed and analyzed by fluorescence imaging. Fluorescence imaging results showed that the distribution of quantum dot-labeled mesenchymal stem cells in normal control rats and diabetic rats was significantly different (Fig. 1): in normal control rats, quantum dot-labeled mesenchymal stem cells were mainly within 3 h. The lungs and the abdomen accumulate, mainly accumulate in the liver after 6h; in diabetic rats, the quantum dot-labeled stem cells mainly accumulate in the pancreatic injury tissue after 6h; the fluorescence of the five organs of heart, liver, pancreas, spleen and lung is taken out. Imaging also confirmed the above results (Fig. 2), suggesting that quantum dot-labeled mesenchymal stem cells actively target pancreatic lesions and play an important role in the treatment of diabetes. In conclusion, this study laid the experimental foundation for the clinical treatment of mesenchymal stem cells for diabetes, and has potential application prospects for diabetes treatment. Figure 1 Quantum dot-labeled mesenchymal stem cells were injected into the body at different time points after tail vein injection. AD was 1 h, 3 h, 6 h and 12 h after injection, respectively. The left side is a normal control rat and the right side is a diabetic rat. Figure 2 Fluorescence imaging analysis of different organs after implantation of quantum dot-labeled mesenchymal stem cells into diabetic rats. Source of the document: Liu H, Tang W, Li C, Lv P, Wang Z, Liu Y, Zhang C, Bao Y, Chen H, Meng X, Song Y, Xia X, Pan F, Cui D, Shi Y. CdSe/ZnS Quantum Dots -Labeled Mesenchymal Stem Cells for Targeted Fluorescence Imaging of Pancreas Tissues and Therapy of Type 1 Diabetic Rats. Nanoscale Res Lett. 2015;10(1):959. Sushi Inari,Tofu Skin Sushi,Inari Tofu Skin Sushi,Tofu Skin Sushi Roll DALIAN HAIBAO FOODS CO., LTD. , https://www.haibaoseafoods.com
