University of Bristol discovers that umbilical cord stem cells can be used to treat congenital heart disease

Researchers have found that stem cells from the umbilical cord may be the key to the next generation of autografts, reducing the number of surgeries that newborns need to undergo due to certain congenital heart diseases.

Congenital heart disease (CHD) is the most common birth defect. In the UK alone, 4,000 newborns are diagnosed with CHD every year. Due to advances in treatment and care technology, 8/10 of CHD children can now grow up healthily.

However, the only treatment for these diseases is prosthetic surgery – replacing damaged tissue with a piece of tissue called a graft. Because the child's heart often grows beyond the repaired graft, the child needs to undergo repeated surgery during childhood.

布里斯托大学发现脐带干细胞可用于治疗先天性心脏病

Now, Massimo Caputo and Paolo Madeddu from the Bristol Heart Institute at the University of Bristol have used umbilical cord and placental stem cells to grow a cell transplant that grows like a living tissue, so it can be combined with childhood heart tissue. Growing. This means that this new graft can replace multiple surgeries that require a larger graft because the child's heart needs only one surgery to grow.

These grafts have been tested in animal models that reflect the true condition of the human body, and the researchers examined their ability to grow and regenerate damaged hearts. The researchers also explored which cells are best suited for transplantation, so they can adjust a range of treatments and solutions based on patient needs. With the completion of the first two experiments, the researchers are preparing to open clinical trials for the treatment of newborns.

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