**Porcine Reproductive and Respiratory Syndrome Virus Live Vaccine (CH-1R Strain)**
1. **High Safety**
The CH-1R strain used in the live vaccine is a weakened version of the PRRS virus, with low virulence, ensuring a high level of safety and stability. It is suitable for large-scale vaccination programs, including free vaccination campaigns.
**Safety Testing:**
Two methods were used to evaluate the safety of the PRRSCH-1R strain:
- **Toxicity Reversion Test:**
Heavy-nose sows at 85–93 days of gestation, which are highly susceptible to the blue-ear virus, were tested. After 3–4 passages, the virus was no longer detectable in serum or nasal swabs. The sows showed no clinical signs of reproductive failure, confirming the genetic stability of the CH-1R strain.
- **Dose-Safety Evaluation:**
The vaccine was tested at different doses, including single and high-dose immunizations. No adverse clinical symptoms were observed in pregnant sows or weaned piglets, and litter sizes remained normal. This confirms that the vaccine is safe for pigs of all ages.
2. **Super Immune Efficacy**
The CH-1R strain is a domestically isolated American strain, with over 98% homology to the Lanner isolate from the 2006 "unidentified fever syndrome."
It provides rapid protection, with antibodies detected as early as one week post-vaccination and effective immunity lasting up to two weeks. This makes it ideal for emergency vaccination scenarios.
The vaccine has a titer above 10âµ.â° TCIDâ‚…â‚€ per head. Its immune protection period can last up to four months.
**Immunoprotection Test:**
- After immunizing piglets aged 28–35 days, IFA antibodies against PRRSV were detected within seven days. By two weeks post-vaccination, 80% of the pigs were protected.
- The minimum effective dose is 10â´.â° TCIDâ‚…â‚€ per head, but our factory standard is set at 10â¶.â° TCIDâ‚…â‚€ per head—100 times higher than the minimum, ensuring maximum effectiveness.
- In long-term studies, pigs vaccinated once with three batches of the vaccine showed 100% protection after five months, leading us to set the immune protection period at four months.
3. **Low Immune Stress**
Healthy pigs vaccinated with the CH-1R strain showed no increase in body temperature, no reduction in feed intake, and normal weight gain, indicating minimal stress on the animals.
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**Porcine Reproductive and Respiratory Syndrome Inactivated Vaccine (CH-1a Strain)**
**Good Safety**
As an inactivated vaccine, the CH-1a strain is inherently safer than live vaccines. It uses a domestic isolate (CH-1a) that has been passaged through Marc-145 cells, cloned, and purified. The virus is then inactivated using chemical agents and combined with medical oil adjuvants.
When administered twice to pregnant sows and piglets, the vaccine caused only minor local reactions in some individuals, with no systemic effects. The pigs maintained normal behavior and appetite, proving its safety. Being inactivated, it eliminates the risk of reversion to a virulent form, making it suitable for breeding pigs.
**Strong Immune Response**
The CH-1a strain offers long-lasting immunity. After the second vaccination, pigs developed strong immunity within 20 days, with over 80% resistance to virulent PRRSV attacks. Its immune protection can last up to six months, making it an ideal choice for PRRS-negative herds.
**Provides Passive Immunity to Newborns**
Sows vaccinated with the CH-1a strain transfer protective antibodies to their piglets via colostrum, offering passive immunity during lactation. Tests show that maternal antibodies can still be detected in piglets as young as 24–28 days old.
**Long Shelf Life**
The inactivated vaccine is stored at 2–8°C. Studies showed that even after 4, 8, and 12 months of storage, the vaccine retained its potency. Pigs vaccinated at different times showed over 90% protection against virulent PRRS challenges, confirming its long-term stability and effectiveness.
COVID-19 Medical Products
These products are used in direct response to the covid-19 pandemic.
The COVID-19 outbreak has resulted in an urgent need for medical products and solutions. In response, Sinoscience has expanded our production into coronavirus related products, including the VTM tube, nucleic acid extraction reagent and extractor and so on.
Covid-19 Medical Products,Vtm Test Kit,Vtm Transport Tube Kit,Vtm Specimen Tube Kit
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