US successfully used brain deep stimulation to successfully treat patients with brain injury

Release date: 2007-08-06

US uses brain deep stimulation to successfully treat patients with brain injury ------------------------------------- -----------------------------------------
Electrodes implanted in the brain to awaken a 6-year coma
A man in the United States was almost completely devoid of consciousness due to brain damage. After 6 years, he miraculously resumed speaking, eating ability and part of his limb function. This miracle is attributed to a recently completed "brain deep stimulation" test in which the electrodes were implanted into the brain. This is the first case of successful treatment of patients with brain injury using electrode stimulation.
The consciousness has almost completely lost in the past six years. The research report was published in the August 2 issue of Nature. At the request of the patient's family, the report did not disclose his name, but stated that he was 38 years old and was an artist before the injury. His brain was severely damaged by an attack. He has been in bed for six years, his consciousness has almost completely lost, and only the eyes and fingers occasionally move slightly. The hospital takes 24-hour round-the-clock monitoring. Medical experts say that in general, patients of this type are unlikely to recover if they cannot recover within the first 12 months of the injury.
However, his mother never gave up hope, still insisted on going to the nursing home to take care of him every week, and kept talking to him. Unfortunately, the latter has never responded. The mother said: "Every time I go home after visiting my son in a nursing home, I always cry out loud. For every mother, it is a torture to watch my son become like this. I only pray for a miracle... ..."
The next day after the operation, I spoke. A few years later, the miracle really happened. After receiving the consent of the patient's parents, a clinic in Ohio in the United States performed a "brain deep stimulation" operation.
The incredible thing happened the next day after the operation. On the same day, the man’s mother chatted with him as usual, but as he spoke, the man suddenly opened his eyes and stared at his mother, then screamed her name! The mother recalled: "At the time, I only felt that I was spinning around. I thought I was dreaming. Did the son speak? And he seemed to be surprised. He didn't understand why he was lying in bed."
This progress has made medical staff very excited. For six months, they conducted random tests on the electrodes in the man's brain. The test found that whenever the electrode is turned on, the man wakes up and talks. He can open the name of some object, make precise gestures, and swallow food. But every time the electrode is turned off, he will fall into a coma again.
At the end of 2005, the doctor decided to turn the electrodes in the brain of the man 12 hours a day and 12 hours off, so that he could stay awake and sleep like normal people.
According to reports, the current patient can not only identify relatives and friends, interact with them, but also respond quickly to the questions raised, but with a gasp when talking. Although he does not open the topic while chatting with people, he can answer others, usually limited to 1-3 words. Joseph Giahi, a neurologist at the Kennedy Rehabilitation Research Institute in New Jersey, said that patients speak clearly and can swallow their own food without relying on intubation to supply nutrients. In addition, the patient also tried to draw out complex movements such as drinking water and combing the cup. Giahi said that because of the long-term bed muscle atrophy, he can actually complete these actions as long as the muscles recover.
The miraculous recovery of the patients surprised the family who had given up on the hope of treatment. His mother said: "He can cry and laugh. The most important thing is that he will call 'Mom' and will say 'Mom I love you.' Every time I see him I will cry, but it is tears of joy."
Stimulation of brain activity with electrical impulses This man's recovery was attributed to the scientists' "brain deep stimulation" clinical trial.
His condition, known as the “Minimum State of Mind” (MCS), is different from the usual coma and “vegetarian”. Although such patients seem to be in a coma, there are occasional short-lived consciousness and slight movements of the eyes or fingers. This is because its thalamus also has limited activity, and the medical community believes that the thalamus has a key coordination role in communication.
Neurologist Giahi explained the experimental principle: using electrical impulses to stimulate the thalamus area can enhance the ability of the original but limited activity. "Signals that drive language and motion are inherent in the brain, and we just enhance them (with electrodes)," he said.
The tester uses a computer to generate a three-dimensional image of the brain. Under the guidance of the image, the electrode is implanted into the patient's brain and the programmable pacemaker battery is connected.
By constantly switching the electrode power supply, the purpose of stimulating the brain is achieved, which is the "brain deep stimulation" technique.
The tester, Ali Rezai of the Neurological Rehabilitation Center at the Klevik Clinical Medicine Foundation in Ohio, said that men's brain conditions improved "significantly and continuously" 16 months after surgery.
"Deep brain stimulation" is often used to treat Parkinson's disease, and American scientists are also trying to treat epilepsy, obsessive-compulsive disorder and depression in this way. However, the first successful treatment of patients with brain injury.
The testers were approved by the US Food and Drug Administration to perform a "brain deep stimulation" on 12 patients with MCS.
Joseph Finns, director of medical ethics at Weill Cornell Medical College in New York City, said that if this series of clinical trials succeeds, it means that MCS is not incurable, which helps to change MCS patients "neglected, only accepts so-called 'guardianship '" without treatment.

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